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KMID : 0438420080150020155
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Korean Journal of Bone Metabolism
2008 Volume.15 No. 2 p.155 ~ p.162
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The Effects of Black Cohosh Root Extract on the Vasomotor Symptom and Bone Metabolism of Postmenopausal Women
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Noh Myoung-Suk
Oh Young-Rim
Kim Heung-Yeol
Eo Wan-Kyo
Kim Hong-Bae
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Abstract
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Objective: To evaluate the effect of black cohosh root extract (BCRE) on vasomotor symptoms and bone mineral
density in postmenopausal women
Method: This prospective randomized clinical trial examined the effects of BCRE on vasomotor symptom, bone
mineral density (BMD), and biochemical markers of bone turnover in 90 postmenopausal women. Treatment included
BCRE (group I, n=30), 0.625 mg conjugated equine estrogen (CEE) (group II, n=30), and control group (group III,
n=30) for 6 months. Kupperman index, BMD and biochemical bone marker were measured at 0, 3 and 6 months after
treatment.
Results: Kupperman index decreased significantly at 6 months and 12 months after treatment in group I and II (P < 0.05). BMD of lumbar spine increased significantly after treatment in group I and II (P < 0.05). Urinary deoxypyridinoline
decreased significantly at 6 and 12 months after treatment in group I and group II (P < 0.05).
Conclusion: BCRE appears to be an effective alternate to hormone therapy for vasomotor symptom, and it may be
especially useful in women with intolerance or contraindication to traditional hormone therapy
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KEYWORD
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Black Cohosh, Kupperman index, Bone mineral density, Markers, biochemical
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